High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis. Issue 1 (6th July 2017)

• Record Type: Journal Article
• Authors: Mangat, Mandeep; Amalakuhan, Bravein; Habib, Sheila; Reyes, Luis F.; Hinojosa, Cecilia A.; Rodriguez, Alejandro H.; Soni, Nilam J.; Anzueto, Antonio; Levine, Stephanie M.; Peters, Jay I.; Aliberti, Stefano; Sibila, Oriol; Rello, Jordi; Witzenrath, Martin; Waterer, Grant W.; Martin-Loeches, Ignacio; Blanquer, Jose; Sanz, Francisco; Marcos, Pedro J.; Solé-Violán, Jordi; Chalmers, James D.; Feldman, Charles; Wunderink, Richard G.; Cruz, Charles S. Dela; Orihuela, Carlos J.; Restrepo, Marcos I.
• Is Part Of: European respiratory journal. Volume 50:Issue 1(2017)
• Publication Date: 2017-07-06
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00013-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

Sepsis affects more than 750 000 Americans each year, with a mortality rate close to 30% [1]. A significant amount of resources has been put into improving our understanding of sepsis and developing new therapies. A push for early sepsis recognition and subsequent timely treatment has led to an interest in inflammatory biomarkers to identify sepsis and its severity [2]. Respiratory dysfunction occurs in up to 81% of cases and a significant proportion requires ventilatory support [1]. Studies have looked at a variety of biomarkers, from inflammatory cytokines such as interleukin (IL)-6 to endothelial proteins like intercellular adhesion molecule-1, to identify patients at greatest risk of developing respiratory compromise [3]. Endocan may have a role as a predictive biomarker for need for mechanical ventilation in patients with severe sepsis http://ow.ly/raKd30bSqTk