Aclidinium bromide improves symptoms and sleep quality in COPD: a pilot study. Issue 6 (22nd June 2017)

• Record Type: Journal Article
• Authors: Magnussen, Helgo; Arzt, Michael; Andreas, Stefan; Plate, Tanja; Ribera, Anna; Seoane, Beatriz; Watz, Henrik; Kirsten, Anne-Marie
• Is Part Of: European respiratory journal. Volume 49:Issue 6(2017)
• Publication Date: 2017-06-22
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00485-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

In patients with chronic obstructive pulmonary disease (COPD), nighttime and early-morning symptoms are associated with an increased rate of exacerbation, hospital admission and reduced survival [1, 2]. Furthermore, patients with COPD frequently have poor sleep quality [3] and reduced physical activity [4, 5]. We hypothesised that nighttime airflow obstruction in patients with COPD is associated with impaired sleep quality, leading to early-morning symptoms and reduced physical activity. Aclidinium statistically improved symptoms, and sleep and physical activity in moderate COPD http://ow.ly/2chV30adLbW