Antacid use and subclinical interstitial lung disease: the MESA study. Issue 5 (19th May 2017) - Restivo, Michaela D.
Idiopathic pulmonary fibrosis (IPF), a prevalent fibrotic idiopathic interstitial lung disease (ILD), is thought to result from recurrent subclinical alveolar epithelial cell (AEC) injury followed by abnormal repair and fibrogenesis [1]. Gastro-oesophageal reflux disease (GORD) has been implicated in AEC injury in IPF [2]. GORD is a prevalent comorbidity in adults with IPF [3], and the gastric enzyme pepsin has been identified in bronchoalveolar lavage fluid of patients with acute IPF exacerbations [4], suggesting a role of micro-aspiration in disease progression. Proton pump inhibitor use is associated with a reduction in subclinical interstitial lung disease http://ow.ly/dbFN30aoRPf