Toll-like receptors in COPD. Issue 5 (23rd May 2017)

• Record Type: Journal Article
• Authors: Hansbro, Philip M.; Haw, Tatt Jhong; Starkey, Malcolm R.; Miyake, Kensuke
• Is Part Of: European respiratory journal. Volume 49:Issue 5(2017)
• Publication Date: 2017-05-23
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00739-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

Chronic obstructive pulmonary disease (COPD) is a major cause of illness and death globally; treatments that effectively halt progression or reverse the disease, or reduce the occurrence and/or severity of exacerbations, are urgently required [1]. The lack of effective treatments results largely from the incomplete understanding of the mechanisms of pathogenesis of COPD. The pathogenesis of this disease is driven by chronic inhalation of noxious particles, often cigarette smoke, that persistently stimulates innate and inflammatory responses [2]. Over time, these responses cause repeated cycles of wound and repair that result in airway remodelling with mucus hypersecretion, collagen deposition, and fibrosis and emphysema. These combine to obstruct the airways and reduce lung function, which is characteristic of the disease. TLR4 and NODs could be potential therapeutic targets in chronic obstructive pulmonary disease http://ow.ly/qaqt30b7YAy