Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice. Issue 2 (16th February 2017)

• Record Type: Journal Article
• Authors: Gallego-Martin, Teresa; Farré, Ramón; Almendros, Isaac; Gonzalez-Obeso, Elvira; Obeso, Ana
• Is Part Of: European respiratory journal. Volume 49:Issue 2(2017)
• Publication Date: 2017-02-16
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02111-2016
• Languages: English
• ISSNs: 0903-1936

Abstract

Obstructive sleep apnoea (OSA) is a very prevalent disorder with well proven mid- and long-term deleterious consequences, such as increased risk of cardiovascular, metabolic and neurocognitive diseases [1]. Recently, considerable data from both animal models and patient studies also suggest that OSA increases the risk of cancer incidence and mortality [2]. Some of these studies indicate that nocturnal hypoxic events experienced by OSA patients as a consequence of recurrent upper airway obstructions may be a main challenge driving tumour progression [3, 4]. Although the clinical and experimental data available do not undoubtedly prove a relationship between cancer and OSA [5], its plausibility has raised the interest of basic and clinical researchers in the field, warranting further investigation [6]. Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice http://ow.ly/BoF6306AnI0