The effect of hypoxia and re-oxygenation on adipose tissue lipolysis in COPD patients. Issue 4 (1st September 2016)

• Record Type: Journal Article
• Authors: Plihalova, Andrea; Bartakova, Hana; Vasakova, Martina; Gulati, Sumeet; deGlisezinski, Isabelle; Stich, Vladimir; Polak, Jan
• Is Part Of: European respiratory journal. Volume 48:Issue 4(2016)
• Page Start: 1218
• Page End: 1220
• Publication Date: 2016-09-01
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00602-2016
• Languages: English
• ISSNs: 0903-1936

Abstract

Severe chronic obstructive pulmonary disease (COPD) is a progressive disease associated with excessive mortality; however, mechanisms driving disease progression remain unclear [1]. A pro-inflammatory state, metabolic impairments and respiratory muscle weakness contribute to deterioration of lung function [1, 2]. Furthermore, a poor COPD prognosis appears to be associated with unintentional weight loss [3, 4], which has been observed in ∼50% of severe COPD patients [5]. Oxygen administration inhibits spontaneous and ANP-stimulated lipolysis in adipose tissue in severe COPD http://ow.ly/ZVg53022Yah