Hydrogen cyanide emission in the lung by Staphylococcus aureus. Issue 2 (26th May 2016)

• Record Type: Journal Article
• Authors: Neerincx, Anne H.; Linders, Ylona A.M.; Vermeulen, Laura; Belderbos, Robert A.; Mandon, Julien; van Mastrigt, Esther; Pijnenburg, Marielle W.; van Ingen, Jakko; Mouton, Johan W.; Kluijtmans, Leo A.J.; Wevers, Ron A.; Harren, Frans J.M.; Cristescu, Simona M.; Merkus, Peter J.F.M.
• Is Part Of: European respiratory journal. Volume 48:Issue 2(2016)
• Page Start: 577
• Page End: 579
• Publication Date: 2016-05-26
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02093-2015
• Languages: English
• ISSNs: 0903-1936

Abstract

Early detection of Pseudomonas aeruginosa in cystic fibrosis (CF) patients is crucial, since eradication in a later stage is extremely difficult [1]. Until now, it has been assumed that hydrogen cyanide (HCN) can be considered as a specific biomarker for P. aeruginosa in exhaled breath [2–5]. Only Burkholderia cepacia is also known to produce HCN in vitro [6, 7], but HCN is not a biomarker for B. cepacia complex infection in vivo [8]. To our knowledge, actual proof that HCN is not produced by other pathogens is lacking. Investigations into the emission of HCN by Staphylococcus aureus, a predominant CF pathogen throughout childhood, have been very limited. In a single report, five strains have been shown to produce low values in vitro [9], and in vivo studies have not been reported. Hydrogen cyanide is produced by S. aureus in vitro and in vivo and is not an exclusive biomarker for P. aeruginosa http://ow.ly/4nsh7y