Ayurvedic treatment induced severe alcoholic hepatitis and non-cirrhotic portal hypertension in a 14-year-old girl. Issue 10 (22nd October 2022)

• Record Type: Journal Article
• Authors: Philips, Cyriac Abby; Ahamed, Rizwan; Abduljaleel, Jinsha K; Rajesh, Sasidharan; Theruvath, Arif Hussain; Raveendran, Resmi; Augustine, Philip
• Is Part Of: Oxford medical case reports. Volume 2022:Issue 10(2022)
• Publication Date: 2022-10-22
• Subjects: Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1093/omcr/omac113
• Languages: English
• ISSNs: 2053-8855

Abstract

ABSTRACT: We report a novel and as yet undescribed clinical scenario in a young girl with liver failure, in whom, the liver histopathology was suggestive of alcoholic hepatitis in the background of hepatoportal sclerosis and incomplete septal cirrhosis. An extensive clinical and investigational evaluation revealed chronic consumption of multiple Ayurvedic herbal medications for seizure disease. Six months after stopping herbal medicines, the repeat liver biopsy demonstrated resolution of alcohol-related changes but persistence of classical features of non-cirrhotic portal hypertension. Analysis of the retrieved agents, including state of the art chemical and toxicology analysis, using gas chromatography and mass spectroscopy methods demonstrated multiple organic and inorganic toxins associated with acute alcohol and arsenic poisoning related hepatoportal sclerosis/incomplete septal cirrhosis in the young girl.