Paradoxical decrease in isoprostane and increase in superoxide dismutase following CPAP withdrawal in OSA. Issue 3 (March 2016)

• Record Type: Journal Article
• Authors: Monneret, Denis; Bonnefont-Rousselot, Dominique
• Is Part Of: European respiratory journal. Volume 47:Issue 3(2016)
• Page Start: 1012
• Page End: 1014
• Publication Date: 2016-03
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01603-2015
• Languages: English
• ISSNs: 0903-1936

Abstract

Stradling et al . [1] have recently published an interesting, unprecedented study assessing the effects of a continuous positive airway pressure (CPAP) withdrawal on oxidative stress in patients already treated for moderate-to-severe obstructive sleep apnoea (OSA). Based on a combination of two different studies, the authors showed that stopping CPAP for 2 weeks ("sham-CPAP" group) significantly decreased the urinary F2-isoprostane concentration, while it increased the activity of the blood superoxide dismutase (SOD), compared with uninterrupted treatment ("CPAP" group). The fall in urinary F2-isoprostane concentration observed in patients who returned to OSA was contrary to the hypothesis tested by the authors, i.e. an increase in oxidative stress when the disease returns. Interestingly, these paradoxical results are corroborated by the strong negative correlation they found between the re-increased oxygen desaturation index values after 2 weeks of CPAP withdrawal and the fall in urinary F2-isoprostane concentration. The authors advanced the hypothesis that intermittent hypoxia for 2 weeks of CPAP withdrawal may have caused a preconditioning protection against oxidative stress. A comment about the paradoxical variations in oxidative stress biomarkers following CPAP withdrawal in OSA http://ow.ly/Uc33R