Treatable traits: toward precision medicine of chronic airway diseases. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Agusti, Alvar; Bel, Elisabeth; Thomas, Mike; Vogelmeier, Claus; Brusselle, Guy; Holgate, Stephen; Humbert, Marc; Jones, Paul; Gibson, Peter G.; Vestbo, Jørgen; Beasley, Richard; Pavord, Ian D.
• Is Part Of: European respiratory journal. Volume 47:Issue 2(2016)
• Page Start: 410
• Page End: 419
• Publication Date: 2016-02
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01359-2015
• Languages: English
• ISSNs: 0903-1936

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms ( i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed ( i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular. A discussion of the concept of "treatable traits" as a way towards precision medicine of chronic airway diseases http://ow.ly/UbJAm