Risk Factors for Development of Endophthalmitis after Open Globe Injury in Children: A Case-Control Study. (17th November 2022)

• Record Type: Journal Article
• Authors: Sen, Pradhnya; Kohli, Gaurav Mohan; Shah, Chintan; Mohan, Amit; Tiwari, Amrita; Ingale, Rashmi; Shenoy, Pratik; Sen, Alok
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 7/8(2022)
• Page Start: 1633
• Page End: 1638
• Publication Date: 2022-11-17
• Subjects: Endophthalmitis -- pediatric -- open globe injury -- trauma -- risk factors -- microbiological profile; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2021.1928237
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Aim: To identify risk-factors for developing endophthalmitis following open globe injury (OGI) in children. Methods: Retrospective, single-center, case-control study of children aged <18 years who sustained OGI. Results: Our cohort of 93 eyes consisted of 30 cases (Group A- endophthalmitis) and 63 controls (Group B- no endophthalmitis). Twenty-four eyes (80%) diagnosed with endophthalmitis presented after 24 hours of injury. The presence of central corneal zone-1 injuries (Odd ratio [OR]: 6.64, p= 0.001) and vitreous in wound (OR: 3.53) were associated with the risk of developing endophthalmitis. (p= < 0.05) Additionally the presence of iris prolapse (OR: 4.76) and posterior capsular rupture (PCR) (OR: 5.80) increased the risk of developing endophthalmitis.(p <0.05) . Streptococci was isolated in 15 eyes, Pseudomonas in 3 eyes, and Candida in 1 eye. The visual outcomes at three months were significantly worse in Group A (LogMAR 1.77±1.06) compared to Group B (LogMAR 0.65±0.68)(p<0.05). Conclusion: Central corneal involvement, vitreous/ iris incarceration and PCR were important risk factors for development of PTE in children