Nucleosides and amino acids, isolated from Cordyceps sinensis, protected against cyclophosphamide-induced myelosuppression in mice. Issue 23 (1st December 2022)

• Record Type: Journal Article
• Authors: Zhang, Yu; Liu, Jie; Wang, Yan; Sun, Chengpeng; Li, Wenjia; Qiu, Jianjian; Qiao, Yanling; Wu, Fan; Huo, Xiaokui; An, Yue; Zhang, Baojing; Ma, Shuangcheng; Zheng, Jian; Ma, Xiaochi
• Is Part Of: Natural product research. Volume 36:Issue 23(2022)
• Page Start: 6056
• Page End: 6059
• Publication Date: 2022-12-01
• Subjects: natural C. sinensis -- artificially-cultivated C. sinensis -- cyclophosphamide -- myelosuppression; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2043307
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The material basis of Cordyceps sinensis (Berk.) Sacc has not yet been well understood and natural C. sinensis resources are very rare. The present study aimed to clarify the substance basis and compare the protective effect of natural and artificially-cultivated C. sinensis against cyclophosphamide (CTX)-induced myelosuppression. Both natural and artificially-cultivated C. sinensis effectively improved CTX-induced decrease of peripheral blood counts and hemopoietic growth factors, pathological changes, and apoptosis of bone marrow. Importantly, artificially-cultivated C. sinensis showed similar capacity compared with natural C. sinensis . Uridine (1), adenosine (2), L-pyroglutamic acid (3), lysinonorleucine (4), 1, 3, 5-trimethoxybenzene (5), D-mannitol (6), L-pyroglutamic acid methyl ester (7), tryptophan (8), and phenylalanine (9) were isolated from bioactivity-guided fraction and identified to attenuate CTX-induced myelosuppression in mice. In conclusions, nucleosides and amino acids represented the effective chemical components in C. sinensis . Artificial cultivation can be used as an effective substitute for natural C. sinensis . Graphical Abstract: UF0001