Monoclonal B-cell Lymphocytosis – a review of diagnostic criteria, biology, natural history, and clinical management. Issue 12 (15th October 2022)

• Record Type: Journal Article
• Authors: Tang, Catherine; Shen, Yandong; Soosapilla, Asha; Mulligan, Stephen P.
• Is Part Of: Leukemia & lymphoma. Volume 63:Issue 12(2022)
• Page Start: 2795
• Page End: 2806
• Publication Date: 2022-10-15
• Subjects: Monoclonal B-cell lymphocytosis -- chronic lymphocytic leukemia -- immune dysfunction -- COVID-19; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2022.2092857
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Since first described almost two decades ago, there has been significant evolution in our definition and understanding of the biology and implications of monoclonal B-cell lymphocytosis (MBL). This review provides an overview of the definition, classification, biology, and natural history of MBL, mainly focused on the dominant CLL-like phenotype form of MBL. The increasingly recognized implications of MBL with respect to immune dysfunction are discussed, particularly in view of the COVID-19 pandemic, along with management recommendations for MBL in the clinic.