Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect. Issue 23 (1st December 2022)

• Record Type: Journal Article
• Authors: Lee, Chia-Lin; Wang, Chien-Ming; Yen, Hung-Rong; Song, Ying-Chyi; Chen, Chao-Jung
• Is Part Of: Natural product research. Volume 36:Issue 23(2022)
• Page Start: 5935
• Page End: 5939
• Publication Date: 2022-12-01
• Subjects: Acanthaceae -- IL-17A inhibition -- indazole alkaloid -- indigodole E -- Qing Dai -- Strobilanthes cusia; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2041633
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new indazole alkaloid, indigodole E (1 ), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia . The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation. Graphical Abstract: UF0001