The Expression of Matrix Metalloproteinases in Eyes with Intraocular Lymphoma. (17th November 2022)

• Record Type: Journal Article
• Authors: Fukutsu, Kanae; Kase, Satoru; Iwata, Daiju; Suzuki, Kayo; Namba, Kenichi; Ishida, Susumu
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 7/8(2022)
• Page Start: 1798
• Page End: 1802
• Publication Date: 2022-11-17
• Subjects: Matrix metalloproteinase -- intraocular lymphoma -- ocular tumor -- tumor infiltration -- non-Hodgkin lymphoma; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2021.1957122
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: The purpose of this study is to investigate matrix metalloproteinases (MMPs) expression in human intraocular lymphoma (IOL). Methods: Two enucleated eyes and seven cell-block samples obtained from patients with IOL who underwent vitrectomy were used. Immunopathological examinations were performed for detection of MMP-2, MMP-9, and TIMP-4 expressions. Results: In the enucleated eye with primary IOL (PIOL), MMP-2 was negative, and MMP-9 and TIMP-4 were positive in the lymphoma cells, while in the enucleated eye with secondary IOL (SIOL), all the molecules were positive. Among the cell-block samples with PIOL, the positive rate in lymphoma cells of MMP-2, MMP-9, and TIMP-4 was 75%, 100%, and 75%, respectively. In the cell-block samples with SIOL, the positive rates of MMP-2, MMP-9, and TIMP-4 were all 100%. Conclusions: MMP-2, MMP-9, and TIMP-4 were expressed in lymphoma cells using the specimens of human IOL, suggesting that MMPs may play an important role in the development of IOL.