New antimicrobial cyclolignan and others constituents from the leaves of Scyphocephalium mannii (Benth. & Hook.f.) Warb. Issue 23 (1st December 2022)

• Record Type: Journal Article
• Authors: Nganteng, Dieu Ne Dort; Melong, Raduis; Maffo, Timoleon; Tchuenguem, Roland T.; Crochet, Aurelien; Dzoyem, Jean Paul; Wafo, Pascal; Bochet, Christian G.; Ngadjui, Bonaventure Tchaleu
• Is Part Of: Natural product research. Volume 36:Issue 23(2022)
• Page Start: 5991
• Page End: 5998
• Publication Date: 2022-12-01
• Subjects: Myristicaceae -- Scyphocephalium mannii -- cyclolignan -- antimicrobial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2056891
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Chemical investigation of the MeOH extract of the leaves of Scyphocephalium mannii (Benth. & Hook.f.) Warb. (Myristicaceae) led to the isolation and characterization of one new metabolite ( + )-(7' S, 8 S, 8' S )-4, 4'-dihydroxy-3, 3', 5, 5'-tetramethoxy-2, 7'-cyclolignan (1 ) along with five known compounds. Their structures were elucidated by spectroscopic means, including 1 D and 2 D NMR, HRESI-MS and by comparison with published data. The absolute configuration of compound 1 was determined by single-crystal X-RAY diffraction. Compound 1 showed moderate antifungal activity against Cryptococcus neoformans with respective MIC and MMC values of 64 and 256 µg/mL. Graphical Abstract: UF0001