Bioactive polyacetylenes from Bidens pilosa L and their anti-inflammatory activity. Issue 24 (17th December 2022)

• Record Type: Journal Article
• Authors: Yan, Zhi; Chen, Zhenshan; Zhang, Ling; Wang, Xiaoming; Zhang, Yaowen; Tian, Zhenhua
• Is Part Of: Natural product research. Volume 36:Issue 24(2022)
• Page Start: 6353
• Page End: 6358
• Publication Date: 2022-12-17
• Subjects: Polyacetylenic glucosides; Bidens pilosa L -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2029432
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new polyacetylenic glucoside together with three known compounds were isolated from the whole herb of Bidens pilosa L. The structure elucidation of these four compounds was employed by combining NMR and HR-MS data as 4- O - β -D-glucopyranosyloxy-1-hydroxy- 6-( E )-tetradecene-8, 10, 12-triyne (1 ), 3- O - β -D-glucopyranosyloxy-1-hydroxy-6-( E )-tetradec- ene-8, 10, 12-triyne (2 ), 2- O - β -D-glucopyranosyloxy-1-hydroxy-5-( E) -tetradecene-7, 9, 11-triy- ne (3 ) and icthyothereol acetate (4 ). Additionally, bioactivity study showed that these compounds have potential anti-inflammatory activity. This study has certain guiding significance for the development and utilisation of polyacetylene compounds in Bidens pilosa L. Graphical Abstract: UF0001