Genetic predisposition to adverse events in Chinese children aged 3-24 months after diphtheria, tetanus, acellular pertussis and haemophilus influenzae type b combined vaccination. (2nd December 2022)

• Record Type: Journal Article
• Authors: Ma, Yujia; Sun, Yexiang; Shen, Peng; Xu, Yuyang; Zhao, Chunyan; Liu, Changfei; Zhou, Zechen; Li, Xiaoyi; Yan, Zeyu; Ding, Kexin; Xiao, Han; Chen, Dafang
• Is Part Of: Expert review of vaccines. Volume 21:Number 12(2022)
• Page Start: 1923
• Page End: 1928
• Publication Date: 2022-12-02
• Subjects: Genetic predisposition -- children -- adverse effects -- DTaP-Hib; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1080/14760584.2022.2144239
• Languages: English
• ISSNs: 1476-0584

Abstract

ABSTRACT: Background: Post-vaccination safety is a major public health concern. The genetic predisposition on immune response has not been clearly identified. Clarifying whether individual genetic predisposition plays a role on adverse events (AEs) is critical for the prevention of AEs. Methods: From July 2019 to June 2020, we performed a case-control study among children aged 3–24 months in seven Chinese provinces. Each child received a combination vaccination against diphtheria, tetanus, acellular pertussis, and Haemophilus influenzae type b (DTaP-Hib). Through daily telephone follow-up, we collected AEs within seven days. Oral swab samples were collected to investigate the effects of single nucleotide polymorphisms (SNPs) on the risk of AEs. Results: 304 participants were included in the study. In univariate analysis, we discovered three protective SNPs (rs452204, OR = 0.67, P = 0.0352; rs9282763 and rs839, OR = 0.64, P = 0.0256) and one risk SNP (rs9610, OR = 2.20, P = 0.0397). In multivariate analysis, the effects of rs452204 and rs839 were found to be stable. The interaction between rs452204 and rs9610 was observed (OR = 7.25, 95% CI: 1.44–36.58, P = 0.0165). Conclusion: Genetic predisposition was associated with the risk of AEs after DTaP-Hib vaccination, emphasizing the potential application in the prevention of AEs.