Hexane extracts from fruit of two varieties of Capsicum chinense Jacq.: their volatile constituents and antiacetylcholinesterase, antileishmanial and antiproliferative activities. Issue 23 (1st December 2022)

• Record Type: Journal Article
• Authors: Toigo, Sandriny E. M.; Fernandes, Cassia C.; Squarisi, Iara S.; Ribeiro, Arthur B.; Tavares, Denise C.; Candido, Ana C. B. B.; Magalhães, Lizandra G.; Moreira, Felipe F.; Crotti, Antônio E. M.; Miranda, Mayker L. D.
• Is Part Of: Natural product research. Volume 36:Issue 23(2022)
• Page Start: 6160
• Page End: 6164
• Publication Date: 2022-12-01
• Subjects: non-polar extracts -- E-caryophyllene -- functional fruit -- Alzheimer's disease -- antiparasitic activity -- tumor cell lines; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2057972
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: This article aims to investigate volatile constituents and antiacetylcholinesterase, antileishmanial and antiproliferative activities of hexane extracts from Capsicum chinense fruit (unripe bode pepper 'HE-UB' and ripe little beak pepper 'HE-RB'). HE-UB and HE-RB were screened by the microplate assay method to determine their antiacetylcholinesterase activity. Both exhibited inhibitory potential, i. e., IC50 = 41.5 and 20.3 µg/mL, respectively. HE-UB (IC50 = 67.19 µg/mL) and HE-RB (IC50 = 38.16 µg/mL) exhibited antileishmanial activity against promastigote forms of Leishmania (Leishmania) amazonensis . In addition, HE-UB and HE-RB demonstrated cytotoxic activity against different human tumor cell lines with IC50 ranging from 325.40 to 425.0 µg/mL. Both GC-FID and GC-MS analyses revealed that the major component in both extracts was E -caryophyllene. In short, HE-RB was more satisfactory than HE-UB in all in vitro activities under evaluation. These findings may be used as initial data for further studies of Capsicum species. Graphical Abstract: UF0001