Triterpenoids from the leaves of Osmanthus fragrans var. aurantiacus with their anti-melanogenesis and anti-tyrosinase activities. Issue 24 (17th December 2022)

• Record Type: Journal Article
• Authors: Le, Duc Dat; Lee, Ye Eun; Lee, Mina
• Is Part Of: Natural product research. Volume 36:Issue 24(2022)
• Page Start: 6414
• Page End: 6420
• Publication Date: 2022-12-17
• Subjects: Anti-melanogenesis -- Osmanthus fragrans var. aurantiacus -- tyrosinase activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2035384
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Excessive production of melanin causes various dermatological disorders including hyperpigmentation. To search for anti-melanogenesis candidates from natural products, we discovered that leaves of Osmanthus fragrans var. aurantiacus (OFA) suppressed melanin production. The extract of OFA leaves and its fractions were subjected to bioactivity-guided separation by targeting active constituents and a total of four triterpenoids were obtained: 3 α, 24-dihydroxyurs-12-en-28 oic acid (1 ), pomolic acid (2 ), maslinic acid (3 ), and corosolic acid (4 ). Compounds 1 and 2 were isolated from this plant for the first time. All compounds were evaluated for their inhibitory activities against melanin production and tyrosinase activity. Active compounds were further investigated to understand their mechanisms of action. Results revealed that they significantly down-regulated TYRP-1 and TYRP-2 expression levels. Our results clarified the whitening property of this plant and provided evidence that active constituents of this plant possessed anti-melanogenesis effect and anti-tyrosinase activity for the first time.