Apoptosis induced by DICO, a novel non-aromatic B-ring flavonoid via a ROS-dependent mechanism in human colon cancer cells. Issue 23 (1st December 2022)

• Record Type: Journal Article
• Authors: Wei, An-Hua; Zeng, Lu; Ruan, Jin-Lan; Zhou, Dao-Nian
• Is Part Of: Natural product research. Volume 36:Issue 23(2022)
• Page Start: 6050
• Page End: 6055
• Publication Date: 2022-12-01
• Subjects: Protoflavone -- apoptosis -- ROS -- NF-kB -- STAT3; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2042283
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: 5, 7-Dihydroxy-2-(1, 2-isopropyldioxy-4-oxo-cyclohex-5-enyl)-chromen-4-one (DICO) is a novel non-aromatic B-ring flavonoid, isolated mainly from Macrothelypteris viridifrons and has anti-tumour properties. In this study, we investigated the cytotoxicity and underlying biochemical pathways leading to cell death, in response to DICO treatment of a human colon cancer cell line HT-29. Our results indicated that DICO induced apoptosis by elevating the generation of reactive oxygen species, which could be quenched by the antioxidants N-acetyl cysteine. In addition, activation of signal transducer and activator of transcription 3 and suppression of nuclear factor kappa B played a crucial role in DICO-induced apoptosis. Overall, our results provide mechanistic insights into the apoptotic action of a potential anti-tumour drug, DICO. Graphical Abstract: UF0001