Characterisation of four new triterpenoid saponins with nitric oxide inhibitory activity from aerial parts of Gouania leptostachya. Issue 23 (1st December 2022)

• Record Type: Journal Article
• Authors: Hang, Nguyen Thi; Bich Thu, Nguyen Thi; Le Ba, Vinh; Van On, Tran; Khoi, Nguyen Minh; Do, Thi Ha
• Is Part Of: Natural product research. Volume 36:Issue 23(2022)
• Page Start: 5999
• Page End: 6005
• Publication Date: 2022-12-01
• Subjects: Gouania leptostachya -- NO inhibition -- gouaniasides VII–IX -- joazeiroside C; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2057971
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Four new triterpenoid saponins (gouaniasides VII–IX [1–3 ] and joazeiroside C [4 ]) and one known triterpenoid (5 ) were isolated from the aerial parts of Gouania leptostachya DC. (Rhamnaceae). Their structures were elucidated via one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, high-resolution electrospray ionisation–mass spectrometry, and analyses of hydrolytic cleavage results. The anti-inflammatory potential of compounds 1–3 was evaluated according to their ability to inhibit the production of nitric oxide (NO) by RAW 264.7 macrophages. All compounds at noncytotoxic concentrations significantly inhibited NO production by macrophages in a concentration-dependent manner. Graphical Abstract: UF0001