Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease. (25th May 2022)

• Record Type: Journal Article
• Authors: Riddell, Anna C; Kele, Beatrix; Harris, Kathryn; Bible, Jon; Murphy, Maurice; Dakshina, Subathira; Storey, Nathaniel; Owoyemi, Dola; Pade, Corinna; Gibbons, Joseph M; Harrington, David; Alexander, Eliza; McKnight, Áine; Cutino-Moguel, Teresa
• Is Part Of: Clinical infectious diseases. Volume 75:Number 11(2022)
• Page Start: 2016
• Page End: 2018
• Publication Date: 2022-05-25
• Subjects: SARS CoV-2 -- B.1.1.7 -- Alpha variant -- immunocompromised -- HIV-1 infection; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac409
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.