Baicalin suppresses the migration and invasion of breast cancer cells via the TGF-β/lncRNA-MALAT1/miR-200c signaling pathway. Issue 46 (18th November 2022)

• Record Type: Journal Article
• Authors: Li, Jiafeng; Liu, Huixin; Lin, Qiwang; Chen, Huajiao; Liu, Liya; Liao, Hongjuan; Cheng, Ying; Zhang, Xiuli; Wang, Zhenlong; Shen, Aling; Chen, Guolong
• Is Part Of: Medicine. Volume 101:Issue 46(2022)
• Page Start: e29328
• Publication Date: 2022-11-18
• Subjects: baicalin -- breast cancer -- invasion -- migration -- TGF-β/lncRNA-MALAT1/miR-200c; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000029328
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Metastasis is the major cause of death and failure of cancer chemotherapy in patients with breast cancer (BC). Activation of TGF-β/lncRNA-MALAT1/miR-200c has been reported to play an essential role during the metastasis of BC cells. The present study aimed to validate the suppression of BC-cell migration and invasion by baicalin and explore its regulatory effects on the TGF-β/lncRNA-MALAT1/miR-200c signaling pathway. We found that baicalin treatment inhibited cell viability and migration and invasion. Mechanistically, baicalin treatment significantly downregulated the expression of TGF-β, ZEB1, and N-cadherin and upregulated E-cadherin on both mRNA and protein levels. Additionally, baicalin treatment significantly downregulated the expression of lncRNA-MALAT1 and upregulated that of miR-200c. Collectively, baicalin significantly suppresses cell viability, migration, and invasion of BC cells possibly by regulating the TGF-β/lncRNA-MALAT1/miR-200c pathway.