Role of Osteopontin in Predicting Short-Term Major Adverse Cardiac Events and Infarction Size in STEMI. Issue 2 (11th October 2021)

• Record Type: Journal Article
• Authors: Belal, Soliman; Farouk, Walid; Khaled, Mahmoud; Abdelbary, Akram
• Is Part Of: Egyptian journal of critical care medicine. Volume 8:Issue 2(2021)
• Page Start: 34
• Page End: 37
• Publication Date: 2021-10-11
• Subjects: MACE -- osteopontin -- STEMI; Intensive care nursing -- Periodicals; 616.02805
• DOI: 10.1097/EJ9.0000000000000025
• Languages: English
• ISSNs: 2090-7303

Abstract

Abstract: Introduction: The outcome of patients with ST elevation myocardial infarction (STEMI) varies widely despite similar presentation and management. Osteopontin (OPN) expression increases with coronary artery disease (CAD) and is associated with increased cardiac myocytes apoptosis and myocardial dysfunction. Objective: To study the role of serum OPN level as a short-term prognostic marker for MACE in patients with STEMI and evaluate its correlation with infarction size (IS). Patients and methods: A prospective, cohort, controlled study was conducted between January 2014 and December 2014, and included all patients admitted to Critical care department, Faculty of medicine, Cairo university with STEMI and matched controls with normal coronaries. Serum OPN level was assessed to all patients on admission. Primary percutaneous intervention (PCI) was the reperfusion strategy for the whole study population. Rest myocardial perfusion imaging was performed 3 days post PCI to assess the IS. Patients were followed up for one month for the occurrence of MACE. Results: Forty consecutive patients with STEMI (29 males, mean age 52 ± 11 years) were compared to 30 matched controls with normal coronaries (19 male, mean age 48.4 ± 9.2 years). Patients with STEMI had higher OPN levels (106 ± 15 ng/mL) on admission than the control subjects (27.5 ± 12.7 ng/mL, P = .01). Mean IS was (21.88 ± 8.99). There was a statistically significant relationship between OPN level and left ventricular (LV) systolic dysfunction ( r : 0.3, P : .045). Yet, there was no statistically significant correlation between OPN level and mortality or reinfarction ( r : 0.2, P : .08, r : 0.12, P : .075, respectively). We found a statistically significant relationship between IS with both LV systolic dysfunction ( r : 0.9, P < .001) and mortality ( r : 0.6, P : .003). OPN level was significantly correlated with the IS ( r : 0.3, P : .045). Discussion: Serum OPN level might be a useful prognostic short-term marker in patients with STEMI after revascularization (regarding LV systolic dysfunction only). Similarly, OPN might be a prognostic marker for IS.