Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model. (6th December 2022)

• Record Type: Journal Article
• Authors: Fragkiadoulaki, Eirini; Tsatsakis, Aristides; Nikitovic, Dragana; Georgiadis, Georgios; Kalogeraki, Alexandra; Kaloudis, Konstantinos; Alegkakis, Athanasios; Karzi, Vasiliki; Mamoulakis, Charalampos
• Is Part Of: Human & experimental toxicology. Volume 41(2022)
• Publication Date: 2022-12-06
• Subjects: acute kidney injury -- contrast media -- kidney -- lycopene -- nephropathy -- resveratrol; Toxicology -- Periodicals; 615.9
• DOI: 10.1177/09603271221145355
• Languages: English
• ISSNs: 0960-3271

Abstract

Oxidative stress appears to possess a central role in CIN pathophysiology. Resveratrol (Res) and lycopene (Lyc) are strong natural antioxidants evaluated in a limited number of CIN animal studies in vivo. The aim of the study was to evaluate the potential renoprotective effects of Res/Lyc in a CIN rabbit model. Twenty-four adult male New Zealand white rabbits were equally assigned into four groups: control (saline), CIN (intravenous iopromide; 7.5 g iodine/kg), Res + CIN (per os Res; 5 mg/kg), and Lyc + CIN (per os Lyc; 4 mg/kg). Serum Cr (sCr); symmetric/asymmetric dimethylarginine (SDMA/ADMA); oxidative stress biomarkers: malondialdehyde; total antioxidant capacity; catalase; glutathione) were evaluated in blood samples at three time points: right after (0 h); 24 h; 48 h after iopromide/saline administration. CD20 + /CD3 + lymphocytes were determined (48 h). All animals were sacrificed at 48 h and both kidneys collected. Oxidative stress biomarkers were measured in renal tissue. sCr and SDMA/ADMA levels increased significantly in CIN compared to all groups. Oxidative stress secondary to CIN in blood/kidneys was suppressed by Res/Lyc. B and T lymphocytes decreased significantly in CIN compared to all groups. The present study provides emerging evidence that Res/Lyc ameliorate CIN by modulating oxidant/antioxidant balance in blood/renal tissue and by inhibiting vasoconstriction/blood cytotoxicity.