PSMA-PET Detection of Unusual Metastases in Castrate-Sensitive Prostate Carcinoma. (26th January 2023)

• Record Type: Journal Article
• Authors: Harris, Nathanial; Tan, Mun Yee; Ng, Michael; Blakey, David; Guerrieri, Mario; Joon, Daryl Lim; Lau, Eddie; Foroudi, Farshad; Armstrong, Alexander; Chao, Michael
• Is Part Of: Clinical nuclear medicine. Volume 48:Number 1(2023)
• Page Start: 85
• Page End: 89
• Publication Date: 2023-01-26
• Subjects: prostate cancer (PCa) -- metastasis -- unusual distribution -- PSMA-PET -- imaging detected; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004469
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: Prostate cancer (PCa) is a multifaceted, heterogeneous disease (with 7 molecular subtypes), which can metastasize to common sites, such as bone, lymph nodes, liver, and lungs. However, with PSMA PET imaging, rare sites of metastasis are increasingly discovered. We report 5 cases of unusual metastases in patients with castrate-sensitive PCa: solitary right inguinal nodal metastasis, solitary abdominal wall metastasis, penile shaft metastases, solitary perineum metastasis, and pleural metastases. These cases further support the use of PSMA-PET imaging in PCa monitoring, with the ability to detect solitary, small volume, and rare sites of metastases, which may not be apparent on conventional imaging.