Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report. Issue 45 (11th November 2022)

• Record Type: Journal Article
• Authors: Fei, Hairong; Liu, Xiaodan; Sun, Lingjie; Shi, Xue; Wang, Wei; Zhao, Hongguo; Zhao, Chunting
• Is Part Of: Medicine. Volume 101:Issue 45(2022)
• Page Start: e31594
• Publication Date: 2022-11-11
• Subjects: B-cell acute lymphoblastic leukemia -- chimeric antigen receptor-modified T cells -- Allogeneic hematopoietic stem cell transplantation -- Immunosuppression -- Fusarium infection; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000031594
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Background: Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. Methods: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor-modified T cells treatment. Results: During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died. Conclusions: Early identification of Fusarium infection based on the characteristic rash and timely antifungal treatment can improve the cure rate.