Impact of the kidney transplantation moratorium in France because of the COVID-19 pandemic: Vincent Bonnemains. (25th October 2022)

• Record Type: Journal Article
• Authors: Bonnemains, V; Le Borgne, F; Savoye, E; Legeai, C; Pastural, M; Bayat-Maokei, S; Lenain, R; Leffondré, K; Couchoud, C; Foucher, Y
• Is Part Of: European journal of public health. Volume 32(2022)Supplement 3
• Publication Date: 2022-10-25
• Subjects: Epidemiology -- Europe -- Periodicals; Public health -- Europe -- Periodicals; 362.109405
• DOI: 10.1093/eurpub/ckac130.224
• Languages: English
• ISSNs: 1101-1262

Abstract

Abstract: Background: The COVID-19 pandemic has resulted in worldwide kidney transplantation (KT) moratoriums. The impacts of these moratoriums on the life expectancy of KT candidates remain unclear. Methods: We simulated the evolution of several French candidate populations for KT using a multistate semi-Markovian approach and according to moratorium durations ranging from 0 to 24 months. The transition rates were modeled from the 63, 927 French patients who began dialysis or were registered on the waiting list for KT between 2011 and 2019. Results: Among the 8, 350 patients active on the waiting list at the time of the French KT moratorium decided on March 16, 2020, for 2.5-months, we predicted 4.0 additional months [CI: 2.8, 5.0] on the waiting list and 42 additional deaths [CI: -70, 150] up to March 16, 2030. In this population, we reported a significant impact for a 9-month moratorium duration: 135 attributable deaths [CI: 31, 257] up to March 16, 2030. Patients who became active on the list after March 2020 were less impacted. Interpretation: The temporary moratorium of KT during a COVID-19 peak in order to free up hospitals' resources doesn't impact patients' 10-year survival if the moratorium does not exceed a prolonged period. Funding. French National Research Agency (ANR-20-COV8-0002-01). Key messages: The French 2020 KT moratorium didn't impair patients' 10-years survival. 9-month or longer moratoriums may impair patients' 10-years survival.