Association between human polyomavirus infection and brain cancer: A systematic review and meta-analysis. (December 2022)

• Record Type: Journal Article
• Authors: Goudarzi far, Fariba; Tambrchi, Vahid; Nahid samiei, Rahil; Nahid samiei, Mahboubeh; Saadati, Hassan; Moradi, Pouya; Keyvanlou, Zahra; Advay, Shoaib; Nili, Marzie; Abdi, Samaneh; Jamalvandi, Tasnim; Arash letafati, ; Behzadpour, Maral; Kamalpour, Maryam; Ebrahimdamavandi, Niayesh; Khatami, Alireza; Kiani, Seyed Jalal; Ghorbani, Saied
• Is Part Of: Microbial pathogenesis. Volume 173(2022)Part A
• Publication Date: 2022-12
• Subjects: Polyomavirus -- JCV -- meta-Analysis -- Brain tumor; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2022.105797
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Aim: The aim of this study was to investigate the prevalence and potential association between the infection with some members of the polyomaviridae family of viruses and development of the brain tumors. Methods: A systematic literature search was performed by finding relevant cross-sectional and case-control studies from a large online database. Heterogeneity, OR, and corresponding 95% CI were applied to all studies by meta-analysis and forest plots. The analysis was performed using Stata Software v.14. Results: Twenty-three articles (33 datasets) were included in the meta-analysis, four (four datasets) of which were case/control studies and the rest were cross-sectional. The pooled prevalence of polyomaviruses among brain cancer patients was 13% (95% CI: 8–20%; I 2 = 96.91%). In subgroup analysis, the pooled prevalence of JCV, SV40, BKV and Merkel cell polyomavirus was 20%, 8%, 6%, and 16%, respectively. An association was found between polyomavirus infection and brain cancer [summary OR 7.22 (95% CI (2.36–22.05); I 2 = 0%)]. The subgroup analysis, based on the virus type, demonstrated a strong association between JCV infection and brain cancer development [summary OR 10.34 (95% CI 1.10–97.42; I 2 = 0%)]. Conclusion: The present study showed a significant association between polyomavirus infection and brain tumors. Moreover, these results suggest that polyomavirus infection may be a potential risk factor for the development of brain cancer. Highlights: The pooled prevalence of polyomaviruses among brain cancer patients was 13% (95% CI: 8–20%; I 2 = 96.91%). In subgroup analysis, the pooled prevalence of JCV, SV40, BKV and Merkel cell polyomavirus among brain cancer patients was 20%, 8%, 6%, and 16%, respectively. An association of polyomavirus infection with brain cancer was [summary OR 7.22 (95% CI (2.36–22.05); I 2 = 0%)]. An association of JCV infection with brain cancer was [summary OR 10.34 (95% CI 1.10–97.42; I 2 = 0%)]. The present study showed a significant association between polyomavirus infection and brain tumors. These results suggest that polyomavirus infection may be a potential risk factor for the development of brain cancer.