Correlation of Clinical Aqueous Flare Grading to Semi-Automated Flare Measurements Using Laser Flare Photometry. (17th November 2022)

• Record Type: Journal Article
• Authors: Halim, Muhammad Sohail; Hasanreisoglu, Murat; Onghanseng, Neil; Tran, Anh N.T.; Hassan, Muhammad; Yilmaz, Mervenur; Segawa, Asadu; Gurelik, Gokhan; Afridi, Rubbia; Ormaechea, Maria Soledad; Uludag, Gunay; Kesim, Cem; Nguyen, Nam V.; Bae, Jeong Hun; Park, Jung Huynh; Do, Diana V.; Ibrahim, Mohamed A.; Sepah, Yasir J.; Nguyen, Quan Dong
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 7/8(2022)
• Page Start: 1906
• Page End: 1912
• Publication Date: 2022-11-17
• Subjects: Laser flare meter -- aqueous flare -- clinical flare grading; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2021.1971723
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To compare laser flare photometry (LFP) measurements of aqueous flare with Standardization of Uveitis Nomenclature (SUN) and modified SUN grading. Methods: In this prospective study with multicenter design, uveitis patients were classified according to SUN and modified SUN grading scales. LFP was performed with Kowa FM-700 flaremeter. Mean LFP values were compared with SUN and MSUN scores. Results: The study included 475 LFP measurements, of which 216, 48, 150, 31, 28 and 2 had 0, 0.5+, 1+, 1.5+, 2+ and 3+ flare, respectively. LFP values were significantly different between each two consecutive steps for both clinical gradings (all P < .05). Cut-off values for modified SUN grading steps were defined as 5.7, 9.7, 15.7 and 43.2 for 0/0.5+, 0.5+/ 1+, 1+/1.5+ and 1.5/2+ borders of clinical flare, respectively. Conclusions: LFP proves to be an objective measurement in analyzing aqueous flare comparable to both SUN and MSUN clinical grading systems.