Pediatric patients with orofacial granulomatosis likely to subsequently develop intestinal Crohn's disease: Brief Report. Issue 6 (28th September 2020)

• Record Type: Journal Article
• Authors: Chen, Kristen L.; Diiorio, Daren A.; Chiu, Yvonne E.; Sokumbi, Olayemi
• Is Part Of: Pediatric dermatology. Volume 37:Issue 6(2020)
• Page Start: 1162
• Page End: 1164
• Publication Date: 2020-09-28
• Subjects: Crohn's disease -- orofacial granulomatosis -- pediatrics; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14390
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition presenting as perioral inflammation in the absence of systemic disease. There is continued debate regarding whether OFG is a distinct clinical disorder or a manifestation of orofacial Crohn's disease. Our retrospective review identified 7 patients diagnosed with OFG between 2000 and 2018 at a tertiary pediatric hospital. Four of the 7 patients subsequently developed Crohn's disease with a median delay of 3.1 years (range 0.4‐6.9 years). This indicates that gastroenterology evaluation with long‐term monitoring for intestinal Crohn's disease is warranted.