Cerebrospinal Fluid Levels of Kininogen‐1 Indicate Early Cognitive Impairment in Parkinson's Disease. Issue 11 (15th August 2020)

• Record Type: Journal Article
• Authors: Markaki, Ioanna; Bergström, Sofia; Tsitsi, Panagiota; Remnestål, Julia; Månberg, Anna; Hertz, Ellen; Paslawski, Wojciech; Sorjonen, Kimmo; Uhlén, Mathias; Mangone, Graziella; Carvalho, Stephanie; Rascol, Olivier; Meissner, Wassilios G.; Magnin, Eloi; Wüllner, Ullrich; Corvol, Jean‐Christophe; Nilsson, Peter; Svenningsson, Per
• Is Part Of: Movement disorders. Volume 35:Issue 11(2020)
• Page Start: 2101
• Page End: 2106
• Publication Date: 2020-08-15
• Subjects: cognition -- kininogen‐1 -- neurodegeneration -- Parkinson's disease; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.28192
• Languages: English
• ISSNs: 0885-3185

Abstract

Abstract: Background: Cognitive impairment is common in patients with PD. Core markers of Alzheimer's dementia have been related also to PD dementia, but no disease‐specific signature to predict PD dementia exists to date. Objectives: The aim of this study was to investigate CSF markers associated with cognition in early PD. Methods: A high‐throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini‐Mental State Examination. Results: Of 69 patients with complete data, 34 had high (≥90) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (<90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen‐1, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders. Conclusions: Kininogen‐1 levels in CSF may serve as a marker of cognitive impairment in PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.