Breast adipose metabolites mediates the association of tetrabromobisphenol a with breast cancer: A case-control study in Chinese population. (1st January 2023)

• Record Type: Journal Article
• Authors: Zhang, Ai; Wang, Rui; Liu, Qianfeng; Yang, Zhengjun; Lin, Xiaohui; Pang, Jing; Li, Xiaoyu; Wang, Dan; He, Jiayu; Li, Jianping; Zhang, Mingyue; Yu, Yue; Cao, Xu-Chen; Chen, Xi; Tang, Nai-jun
• Is Part Of: Environmental pollution. Volume 316(2023)part 1
• Publication Date: 2023-01-01
• Subjects: Tetrabromobisphenol A -- Breast cancer -- Metabolomics -- Mediation analysis -- Phosphatidylcholine; TBBPA Tetrabromobisphenol A -- THs Thyroid hormones -- HPGA Hypothalamic-pituitary-gonadal axis -- TME Tumor microenvironment -- SPE Solid phase extraction -- UPLC-MS/MS Ultra-performance liquid chromatography tandem mass spectrometry -- HPLC-MS/MS High-performance liquid chromatography tandem mass spectrometry -- BPS Bisphenol S -- BPF Bisphenol F -- BPB Bisphenol B -- BPAP Bisphenol Z Bisphenol AP -- BPP Bisphenol P -- BPAF Bisphenol AF -- TBBPS Tetrabromobisphenol S -- PP Polypropylene -- RSD Relative standard deviation -- LOD Limit of detection -- LOQ Limit of quantification -- QC Quality control -- XIC Extracted ion chromatogram -- PSM Propensity score matching -- FDR False discovery rate -- PCA Principal components analysis -- PLS-DA Partial least squares discriminant analysis -- FC Fold change -- BPs Bisphenol analogues -- ACME Indirect effects -- PC (16:0/16:0) Dipalmitoyl phosphatidylcholine -- BFRs Brominated flame retardants -- TR Thyroid hormone receptor; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2022.120701
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Studies exploring the association of tetrabromobisphenol A (TBBPA) with breast cancer and related mechanisms are limited. To investigate the relationship between TBBPA levels in breast adipose and breast cancer, we carried out case-control research. As well as further examine the mediating role of adipose metabolites between TBBPA and breast cancer using the metabolomics approach. In this study, the concentration of TBBPA was determined utilizing ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) after a solid phase extraction (SPE) pretreatment. High-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) was employed to analyze adipose metabolomics. Evaluation of metabolites linked to TBBPA exposure and breast cancer was performed utilizing mediation analysis. With an estimated OR (95%CI) of 1.153 (1.023, 1.299), TBBPA was firmly linked with breast cancer. We also used propensity score matching analysis and sensitivity analysis to reduce the effect of confounding factors on the results. Metabolomics of adipose suggested significant perturbation in the linoleic acid metabolism pathway. In addition, for PC (16:0/16:0) as phospholipids, a mediation effect on the associations of TBBPA exposure with breast cancer risks was observed (estimated mediation percentage: 56.58%). Understanding the relationship between TBBPA exposure and the risk of breast cancer may be facilitated by the findings, which point to potential mediation metabolites. Graphical abstract: Image 1 Highlights: First mediation analysis of the relationship between TBBPA and breast cancer risk. TBBPA were associated with increased risk of breast cancer. Metabolomics indicated a perturbation of the linoleic acid metabolic pathway. Phospholipids may mediate the association between TBBPA exposure and breast cancer.