A Multifunctional Microfluidic Platform for High‐Throughput Experimentation of Electroorganic Chemistry. (11th September 2020)

• Record Type: Journal Article
• Authors: Mo, Yiming; Rughoobur, Girish; Nambiar, Anirudh M. K.; Zhang, Kara; Jensen, Klavs F.
• Is Part Of: Angewandte Chemie. Volume 132:Number 47(2020)
• Page Start: 21076
• Page End: 21080
• Publication Date: 2020-09-11
• Subjects: electroanalysis -- electrosynthesis -- flow chemistry -- high-throughput experimentation -- microfluidics; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202009819
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Electroorganic synthesis is a promising tool to design sustainable transformations and discover new reactivities. However, the added setup complexity caused by electrodes in the system impedes efficient screening of reaction conditions. Herein, we present a microfluidic platform that enables automated high‐throughput experimentation (HTE) for electroorganic synthesis at a 15‐microliter scale. Two HTE modules are demonstrated: 1) the rapid electrochemical reaction condition screening for a radical–radical cross‐coupling reaction on micro‐fabricated interdigitated electrodes, and 2) measurements of kinetics for mediated anodic oxidations using the microliter‐scale cyclic voltammetry. The presented modular approach could be deployed for a range of other electroorganic chemistry applications beyond the demonstrated functionalities. Abstract : An automated electrochemistry screening platform based on a single‐droplet microfluidic reactor enables multifunctional capabilities for investigation of electroorganic synthesis. Reaction condition screening of an electrochemical radical–radical cross‐coupling reaction and measurements of kinetics for two mediated anodic oxidation reactions are realized with fast turnover time and minimal reagent consumption.