Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on. Issue 17 (18th August 2020)

• Record Type: Journal Article
• Authors: Miller, Steven M.
• Is Part Of: Journal of comparative neurology. Volume 528:Issue 17(2020)
• Page Start: 3171
• Page End: 3197
• Publication Date: 2020-08-18
• Subjects: binocular rivalry -- bipolar disorder -- bistable oscillator -- caloric vestibular stimulation -- consciousness -- interhemispheric switch -- sticky switch; Comparative neurobiology -- Periodicals; Neurology -- Periodicals; 616
• DOI: 10.1002/cne.24943
• Languages: English
• ISSNs: 0021-9967

Abstract

Abstract: Science and medicine aim to identify verifiable and replicable truths. However, the paths to such truths are frequently characterized by swinging pendulums of opposing perspectives. This is especially so in human neuroscience and the brain‐based clinical sciences, where the target of investigation is the most complex of all biological systems. This article overviews a set of interrelated neuroscientific and clinical hypotheses, models, experiments, and predictions with which I have been involved for the last two decades. Traversing visual neuroscience, consciousness science, genetics, chronobiology, and biological and clinical psychiatry, the work illustrates how developments in science and medicine can occur through a combination of synthesis, serendipity, and experimentation. The article also reflects on doing science with the inimitable John "Jack" Pettigrew, and outlines how Pettigrew and I conceived, proposed, tested, and developed two new scientific models—one on neural mechanisms of binocular rivalry, the other on the pathophysiology of bipolar disorder. I also provide an update on various aspects of our models and data, and describe lessons learned from Pettigrew on how perspectives in science exhibit their own fluctuations, ironically like the very phenomena on which we worked. Abstract : Two decades ago Jack Pettigrew and I proposed the interhemispheric switch model of binocular rivalry and the sticky switch model of bipolar disorder. Here I describe the genesis, development, supporting data, and current status of these models. I also reflect on doing science with Pettigrew, his remarkable life in science, and how perspectives in science and medicine can fluctuate like the very phenomena on which we worked.