2‐Methoxypropanol‐1 [MAK Value Documentation in German language, 2018]. Issue 2 (24th April 2018)

• Record Type: Journal Article
• Authors: Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 3:Issue 2(2018)
• Page Start: 753
• Page End: 766
• Publication Date: 2018-04-24
• Subjects: 2‐Methoxypropanol‐1 -- 2‐Methoxy‐1‐hydroxypropan -- 2‐Methoxypropan‐1‐ol -- 2‐Methoxypropanol -- 1‐Propylenglykol‐2‐methylether -- 2‐Methoxy‐1‐propanol -- Wirkungsmechanismus -- Toxikokinetik -- Metabolismus -- (sub)akute Toxizität -- (sub)chronische Toxizität -- Reizwirkung -- Reproduktionstoxizität -- Fertilität -- Entwicklungstoxizität -- Genotoxizität -- Spitzenbegrenzung -- fruchtschädigende Wirkung -- krebserzeugende Wirkung -- keimzellmutagene Wirkung -- Hautresorption -- sensibilisierende Wirkung -- Arbeitsstoff -- maximale Arbeitsplatzkonzentration -- MAK‐Wert -- Toxizität -- Gefahrstoff; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.mb158947d0065
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for 2‐methoxypropanol‐1 [1589‐47‐5 ]. Available publications and unpublished study reports are described in detail. Critical effects of 2‐methoxypropanol‐1 are its irritancy and teratogenicity. A MAK value of 5 ml/m 3 had been set. By analogy with 2‐methoxypropylacetate‐1, this value is now reaffirmed. Also, by analogy with 2‐methoxypropylacetate‐1 Peak Limitation Category I with excursion factor of 2 is set. 2‐Methoxypropanol‐1 ether remains assigned to Pregnancy Risk Group B and also remains designated with an "H" (for substances that can be absorbed through the skin in toxicologically relevant amounts).