Addendum to Ethylene glycol dinitrate [BAT value documentation, 2018]. Issue 3 (25th July 2019)

• Record Type: Journal Article
• Authors: Klotz, K.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 4:Issue 3(2019)
• Page Start: 1628
• Page End: 1630
• Publication Date: 2019-07-25
• Subjects: ethylene glycol dinitrate -- EGDN -- glycide nitrate -- glycol dinitrate -- nitroglycide -- BAT value -- biological guidance value -- occupational exposure -- toxicity; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb62896e2319
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value (BAT value) for ethylene glycol dinitrate [CAS No. 628‐96‐6 ] in 2017. Aim of this re‐evaluation was the lowering of the MAK value from 0.05 to 0.01 mL/m 3 (for the sum of ethylene glycol dinitrate, nitroglycerin and propylene glycol dinitrate). The former BAT value of 0.3 µg ethylene glycol dinitrate/L blood was based on a correlation between external and internal exposure to the former MAK value of 0.05 ml/m 3 . The limit of detection of the applied analytical method was 0.2 µg ethylene glycol dinitrate/L blood. Correlating values of ethylene glycol dinitrate to the present MAK value would result in values below the limit of detection. Further studies and more sensitive analytical methods are missing. Therefore, the BAT value was withdrawn.