Anilin [MAK Value Documentation in German language, 2018]. Issue 1 (15th February 2018)

• Record Type: Journal Article
• Authors: Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 3:Issue 1(2018)
• Page Start: 27
• Page End: 45
• Publication Date: 2018-02-15
• Subjects: Anilin -- Aminobenzol -- Phenylamin -- Wirkungsmechanismus -- Toxikokinetik -- Metabolismus -- (sub)akute Toxizität -- (sub)chronische Toxizität -- Reizwirkung -- allergene Wirkung -- Reproduktionstoxizität -- Fertilität -- Entwicklungstoxizität -- Genotoxizität -- Kanzerogenität -- Spitzenbegrenzung -- fruchtschädigende Wirkung -- krebserzeugende Wirkung -- keimzellmutagene Wirkung -- Hautresorption -- sensibilisierende Wirkung -- Arbeitsstoff -- maximale Arbeitsplatzkonzentration -- MAK‐Wert -- Toxizität -- Gefahrstoff; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.mb5263d0064
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for aniline [62‐53‐3 ]. Available publications and unpublished study reports are described in detail. Healthy male and female volunteers showed increased methemoglobin values in a 6‐hour‐inhalation‐study with exposure to 2 ml aniline/m 3 . The median methemoglobin augmentation was 0.5 % from the base level of 0.7 % to 1.2 % methemoglobin. Even taking into account the highest observed increase of methemoglobin, 8 hour‐exposure time and the increased respiratory volume at the workplace, a methemoglobin value of more than 5 % would not be expected. Based on this, the MAK value for aniline of 2 ml/m 3 (7.7 mg/m 3 ) is confirmed. Aniline is still assigned to Peak Limitation Category II, because systemic effects are critical and the excursion factor of 2 is confirmed. Skin contact is expected to contribute significantly to the systemic toxicity. Therefore, the designation with an "H" is confirmed. Aniline continues to be designated with "Sh" and assigned to Carcinogenicity Category 4.