Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis. Issue 47 (19th October 2020)

• Record Type: Journal Article
• Authors: Soliman, Nancy; Gasser, Gilles; Thomas, Christophe M.
• Is Part Of: Advanced materials. Volume 32:Issue 47(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-19
• Subjects: anticancer -- medicinal inorganic chemistry -- metals in medicine -- nanomaterials -- nanomedicine; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202003294
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Ru(II) polypyridyl complexes are compounds of great interest in cancer therapy due to their unique photophysical, photochemical, and biological properties. For effective treatment, they must be able to penetrate tumor cells effectively and selectively. The development of nanoscale carriers capable of delivering Ru(II) polypyridyl complexes has the potential to passively or selectively enhance their cellular uptake in tumor cells. Many different strategies have been explored to incorporate Ru(II) polypyridyl complexes into a variety of nanosized constructs, ranging from organic to inorganic materials. Herein, recent developments in nanomaterials loaded with Ru(II) polypyridyl complexes are highlighted. Their rational design, preparation, and physicochemical properties are described, and their potential applications in cancer therapy are eventually discussed. Abstract : For effective treatment in cancer therapy, Ru(II) polypyridyl complexes must be able to penetrate tumor cells effectively and selectively. The development of nanoscale carriers capable of delivering these complexes has the potential to passively or selectively enhance their cellular uptake in tumor cells. Recent developments in nanomaterials loaded with Ru(II) polypyridyl complexes are highlighted.