SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs. Issue 66 (11th November 2020)

• Record Type: Journal Article
• Authors: Wosniok, Paul R.; Knopf, Christopher; Dreisigacker, Sandra; Orozco‐Rodriguez, J. Manuel; Hinkelmann, Bettina; Mueller, Peter P.; Brönstrup, Mark; Menche, Dirk
• Is Part Of: Chemistry. Volume 26:Issue 66(2020)
• Page Start: 15051
• Page End: 15051
• Publication Date: 2020-11-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202003845
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Invited for the cover of this issue is the group of Dirk Menche at the University of Bonn. The image depicts the natural product leupyrrin A1 and a synthetic leupylog in balance on an IC50 weighing scale. Read the full text of the article at 10.1002/chem.202002622 . Abstract : " The first set of relevant SAR data for the leupyrrins revealed the high importance of the macrocyclic core, a certain flexibility of the diacid fragment, and high tolerance of the side chain. The leupylogs, which are characterized by a substitution of dihydrofuran side chain by a mere aryl substituent, retain the potent biological activity of the parent natural products . " Read more about the story behind the cover in the Cover Profile and about the research itself on page 15074 ff. (DOI: 10.1002/chem.202002622 ).