2022-RA-1549-ESGO Vulvar primary melanoma: Report of Six cases and review of literature. (20th October 2022)

• Record Type: Journal Article
• Authors: Jellali, Amani; Bouhani, Malek; Chalouati, Takoua; Sakhri, Saida; Khessairi, Nayssem; Bouaziz, Hanen; Rahal, Khaled
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 2
• Page Start: A449
• Page End: A449
• Publication Date: 2022-10-20
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-ESGO.970
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: Optimal treatments for vulvar melanomas (VM) have not been identified. VM has a poor prognosis due to late diagnosis and early dissemination. Only a limited amount of literature exists on this condition. This study elucidates the effect of current treatment. Methodology: We report all patients diagnosed with malignant melanoma in the vulva at Salah Azaiez Institute, between June 2011 and May 2022, from retrospective chart review and histologic analysis. Results: A total of 6 patients were included. The mean age at the time of diagnosis was 41. 5 years. The majority of the melanomas were nodular. Superficially spreading melanomas only on the vulva were found in four patients; however, extension on the vagina was found in two cases. Five patients underwent radical surgery: total vulvectomy with bilateral inguinofemoral lymphadenectomy. One patient underwent wide local excision and sentinel lymph node investigation. This patient had local recurrence after 3 months; she had a radical vulvectomy and lymph node dissection. Histological findings showed free margins in all the patients. The median disease-free survival was 7 months and the median overall survival time was almost 14 months. Conclusion: Vulvar melanomas differ from nongenital cutaneous melanoma in epidemiologic characteristics and treatment paradigms. The prognosis is generally poor, with a high tendency to loco-regional and distant metastasis; thus, early diagnosis and staging are very important.