2022-RA-443-ESGO Lymph node involvement in early-stage cervical cancer: is the lymphangiogenesis a risk factor? Results of MICROCOL study. (20th October 2022)

• Record Type: Journal Article
• Authors: Tantari, Matteo; Bogliolo, Stefano; Morotti, Matteo; Balaya, Vincent; Boutitie, Florent; Buenerd, Annie; Magaud, Laurent; Lécuru, Fabrice; Guani, Benedetta; Mathevet, Patrice
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 2
• Page Start: A11
• Page End: A12
• Publication Date: 2022-10-20
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-ESGO.25
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: In patients with cervical cancer, the presence of tumoral lymph-vascular space invasion (LVSI) is the main risk factor for pelvic lymph node metastasis (PLNM). The objective of this study was to evaluate the presence of several markers of lymphangiogenesis in early-stage cervical cancer and their correlation with PLNM and tumoral recurrence. Methodology: Patients with early-stage cervical carcinoma underwent sentinel lymph node (SLN) sampling in association with complete pelvic lymph node dissection. Primary tumors were stained with the following markers: Ki67, D2–40, CD31 and VEGF-C. A 3 years follow-up was performed to evaluate the disease-free survival. Results: Overall, 14 patients (18.6%) had PLNM. Positive LVSI was seen in 29 patients (38.6%). There was a significant correlation between LVSI evidenced by H/E staining and PLNM (p<0.001). There was no correlation between high Ki67, CD31, D2–40, and VEGF-C staining with PLNM or tumor recurrence. Conclusion: Our data support lymphatic spread does not require the proliferation of new lymphatic endothelial cells in early-stage cervical cancer. These results emphasize the importance of pre-existing peritumoral lymphatic vessels in the metastatic process in early cervical cancer. None of the markers of lymphangiogenesis and proliferation assessed in this study were predictive of PLNM or recurrence.