2022-RA-1246-ESGO The impact on survival of FDG-TEP versus surgical pretherapeutic paraaortic lymph node staging in locally advanced cervical cancer before concomitant chemoradiation. A retrospective single-center cohort. (20th October 2022)

• Record Type: Journal Article
• Authors: Hajj, Houssein El; Bogart, Emilie; Benna, Mehdi; Oudoux, Aurore; Ceugnart, Luc; Chevalier, Hortense; Hudry, Delphine; Tinier, Florence Le; Leblanc, Eric; Deley, Marie Cecile Le; Narducci, Fabrice; Cordoba, Abel; Gomez, Carlos Martinez
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 2
• Page Start: A49
• Page End: A49
• Publication Date: 2022-10-20
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-ESGO.107
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: Aortic lymph node (LN) involvement represents one of the essential prognosis factors and defines the extent of external definitive chemoradiation. Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) remains the most accurate imaging technique to assess the extrauterine dissemination of the tumor unless it fails to detect between 10% to 15% of metastasis in aortic area. Despite false negatives of imaging, it remains unclear if surgical staging (SS) improves disease-free survival (DFS) and overall Survival (OS). We aim to determine the impact of SS on efficacy. Methodology: From 01/2009 to 12/2019, we retrospectively reviewed all consecutive patients (pts) addressed for brachytherapy diagnosed with locally advanced cervical cancer FIGO 2009 stages IB2-IVa with negative PET-CT uptake in the paraaortic area. OS and DFS were estimated from initial biopsy using the Kaplan-Meier method. Treatment effect of paraaortic and imaging LN staging (cohort 1) versus exclusive imaging staging (cohort 2) was estimated using Cox models adjusted on baseline characteristics which are significantly different between groups (age, BMI, diabetes, ECOG performance status, pelvic LN status, FIGO stage). Adjusted hazard ratio (adjHR) were estimated with 95% confidence interval (CI95%). Results: Among the 225 pts analyzed, 178 pts were in cohort 1 and 47 in cohort 2. Respectively for cohort 1 and 2, median age was 47 and 58 years, ECOG≥1 for 10 (6%) and 22 pts (47%) and FIGO stage ≥III for 72 (40%) and 29 pts (62%). Five-years OS was 79% (CI95%: 72–85) and 52% (36–65) respectively, with adjHR=0.71 (0.37–1.36) and p=0.30. Five-years DFS was 67% (60–74) and 42% (27–56), with adjHR=0.81 (0.47–1.42) and p=0.47. Conclusion: In this single-institution retrospective serie, SS appears not significantly different for OS and DFS compared to TEP-CT staging. However, the baseline characteristic of both groups was different. Prospective randomized trials should further evaluate the role of surgical staging.