2022-RA-589-ESGO The effect of major postoperative complications on recurrence and long-term survival after cytoreductive surgery for ovarian cancer. (20th October 2022)

• Record Type: Journal Article
• Authors: Angeles, Martina Aida; Hernández, Alicia; Pérez-Benavente, Asunción; Cabarrou, Bastien; Spagnolo, Emanuela; Rychlik, Agnieszka; Daboussi, Amel; Migliorelli, Federico; Bétrian, Sarah; Ferron, Gwénaël; Gil-Moreno, Antonio; Guyon, Frédéric; Martinez, Alejandra
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 2
• Page Start: A241
• Page End: A242
• Publication Date: 2022-10-20
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-ESGO.519
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: To assess the impact on survival of major postoperative complications and to identify the factors associated with these complications in patients with advanced ovarian cancer after cytoreductive surgery. Methodology: We designed a retrospective multicenter study collecting data from patients with IIIC-IV FIGO Stage ovarian cancer who had undergone either primary debulking surgery (PDS), early interval debulking surgery (IDS) after 3–4 cycles of neoadjuvant chemotherapy, or delayed debulking surgery (DDS) after 6 cycles, with minimal or no residual disease, from January 2008 to December 2015. Univariable and multivariable analyses were conducted to identify factors associated with major surgical complications (≥Grade 3). We assessed disease-free survival (DFS) and overall survival (OS) rates according to the occurrence of major postoperative complications. Results: 549 women were included. The overall rate of major surgical complications was 22.4%. Patients who underwent PDS had a higher rate of major complications (28.6%) than patients who underwent either early IDS (23.2%) or DDS (14.0%). Multivariable analysis revealed that extensive peritonectomy and surgical timing were associated with the occurrence of major complications. Median DFS and OS were 16.9 months (95%CI=[13.7–18.4]) and 48.0 months (95%CI=[37.2–73.1]) for the group of patients with major complications, and 20.1 months (95%CI=[18.6–22.4]) and 56.7 months (95%CI=[51.2–70.4]) for the group without major complications. Multivariable analysis revealed that major surgical complications were significantly associated with DFS, but not with OS. Conclusion: Patients who experienced major surgical complications had reduced DFS, compared with patients without major morbidity. Extensive peritonectomy and surgical timing were predictive factors of postoperative morbidity.