2022-RA-1032-ESGO Evaluation of intraoperative HPV test as an early marker of residual disease after HSIL surgical treatment. a prospective multicenter study. Preliminary results. (20th October 2022)

• Record Type: Journal Article
• Authors: Bradbury, Melissa; Acosta, Ursula; Quesada, Alfonso; Lopez-Fernandez, Jose A; Quilez, Jose; Centeno, Cristina; Gil, Antonio
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 2
• Page Start: A379
• Page End: A379
• Publication Date: 2022-10-20
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-ESGO.813
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: Objective: To evaluate if the intraoperative human papillomavirus (IOP-HPV) test has the same prognostic value as the HPV test performed 6 months after treatment of high-grade squamous intraepithelial Lesion (HSIL) to predict treatment failure. Methodology: Design: Prospective multicenter cohort studySetting: 22 Referral Hospitals in Spain.Population: 1824 women treated for cervical HSIL by Loop Electrosurgical Excision between May 2020 and December 2021 After LEEP an HPV test was performed immediately after excision using a Cobas (83%) or other genotyping test. Subsequently, pacients were followed with citology and HPV test, 6, 12 and 24 months after treatment. The IOP-HPV test was compared with HPV test 6 months after procedure and with surgical margins in order to detect residual disease. Results: We described results of the first 992 cases with the 6 month co-test performed. IOP HPV test was feasible (valid result 98, 5%). IOP-HPV was positive in 40%, while only 25% at 6 month test. We observed association between the IOP and 6 month HPV test (ChiSquare p= 0.0001), IOP HPV positivity and abnormal citology at 6 months (p=0.063), and positive IOP HPV test and positive surgical margins.(p=0.0001) Conclusion: Preliminary results show that IOP HPV test could be a satisfactory prognostic factor of cervical HSIL treatment result.