2022-RA-1465-ESGO Randomised trial of population based BRCA testing in Ashkenazi Jews: long term secondary lifestyle behavioural outcomes. (20th October 2022)

• Record Type: Journal Article
• Authors: Burnell, Matthew; Gaba, Faiza; Sideris, Michail; Sobocan, Monika; Rakshit, Rakshit; Sanderson, Saskia; Loggenberg, Kelly; Gessler, Sue; Side, Lucy; Brady, Angela; Dorkins, Huw; Wallis, Yvonne; Jacobs, Chris; Legood, Rosa; Beller, Uziel; Tomlinson, Ian; Wardle, Jane; Menon, Usha; Jacobs, Ian; Manchanda, Ranjit
• Is Part Of: International journal of gynecological cancer. Volume 32(2022)Supplement 2
• Page Start: A402
• Page End: A402
• Publication Date: 2022-10-20
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2022-ESGO.861
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Introduction/Background: Ashkenazi-Jewish (AJ) population-based BRCA -testing is acceptable, does not detrimentally impact psychological well-being or quality of life, is cost-effective and amplifies primary prevention for breast cancer (BC) ovarian cancer (OC). However, prospective data describing lifestyle impact are lacking. We report long-term results of a population-based BRCA -testing randomised controlled trial (RCT) on lifestyle behaviour and cancer-risk perception. Methodology: We designed a two-arm RCT (ISRCTN-73338115, GCaPPS): (a)Population-Screening (PS) arm; (b) family-history (FH)/Clinical-criteria testing arm. Women and men >18-years in the North-London AJ-population were offered informed pre-test genetic counselling and BRCA testing. Participants were recruited through self-referral. Exclusions included: prior BRCA -testing or first-degree relatives of BRCA -carriers. The intervention included genetic-testing for three AJ BRCA -mutations: 185delAG(c.68_69delAG), 5382insC(c.5266dupC) and 6174delT(c.5946delT). This was undertaken for all participants in the PS-arm; and participants fulfilling FH/clinical-criteria in the FH-arm. Patients filled customised/validated questionnaires at baseline/1-year/2-years/3-years follow-up. Outcome measures included lifestyle/behavioural outcomes. Generalized linear-mixed models adjusted for covariates and appropriate contrast-tests were used for between-group and within-group analysis of lifestyle and behavioural outcomes along-with evaluating factors associated with these outcomes. Outcomes are adjusted for multiple testing (Bonferoni method), with p<0.0039 considered significant. Results: 1034 participants were randomized to PS (n=530) or FH (n=504) arms. No significant difference was identified between PS and FH-based BRCA -testing approaches for dietary fruit/vegetable/meat consumption, vitamin intake, alcohol quantity/frequency, smoking behaviour (frequency/cessation), physical activity/exercise or routine breast mammogram screening behaviour, with outcomes not affected by BRCA test result. Cancer-risk perception decreased with time following BRCA -testing with no difference between FH/PS approaches. The risk was found to be lowest in BRCA -negative participants. Men consume fewer fruits, vegetables and vitamins but more meat and alcohol than women (p<0.001). Conclusion: Population-based and FH-based AJ BRCA -testing have similar long-term life-style impacts for smoking, alcohol, dietary fruit/vegetable/meat/vitamin, exercise, breast screening participation and reduced cancer-risk perception.