Injectable carboxymethyl chitosan-genipin hydrogels encapsulating tea tree oil for wound healing. (1st February 2023)

• Record Type: Journal Article
• Authors: Hu, Kepeng; Jia, Erna; Zhang, Qimeng; Zheng, Wei; Sun, Rongjiao; Qian, Mengao; Tan, Ying; Hu, Wanle
• Is Part Of: Carbohydrate polymers. Volume 301(2023)Part B
• Publication Date: 2023-02-01
• Subjects: Injectable hydrogel -- Wound healing -- Tea tree oil -- Carboxymethyl chitosan -- Anal fistula; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.120348
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Injectable hydrogel is of interesting for wound healing due to it can be used as carriers of bioactive molecules for the reparation of tissues with minimal invasiveness. However, the integration of lipid-soluble substances into hydrogel network is difficult because of the polarity differences. Here, the tea tree oil (TTO) is encapsulated into the hydrogel network via a previous emulsification process, and a tough and antibacterial injectable hydrogel is synthesized by the Schiff base reaction between carboxymethyl chitosan (CMCS) and genipin (GP). CMCS is served as both an emulsifier and a gel-forming material to construct the heterogeneous hydrogel. The obtained hydrogels present high adhesive strength (∼162.75 kPa), great antibacterial properties (over 90 %) and excellent biocompatibility. Moreover, an anal fistula-like wound healing experiment concluded that the heterogeneous hydrogel has good slow-release properties of TTO for an accelerate healing process, this hydrogel shows great potential for the treatment of complex anal fistula wounds. Graphical abstract: Unlabelled Image