Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications. (1st February 2023)

• Record Type: Journal Article
• Authors: Pardeshi, Chandrakantsing V.; Kothawade, Rucha V.; Markad, Ashwini R.; Pardeshi, Sagar R.; Kulkarni, Abhijeet D.; Chaudhari, Prashant J.; Longhi, Marcela R.; Dhas, Namdev; Naik, Jitendra B.; Surana, Sanjay J.; García, Mónica C.
• Is Part Of: Carbohydrate polymers. Volume 301(2023)Part B
• Publication Date: 2023-02-01
• Subjects: Captisol (91886200) -- Sulfobutylether β-cyclodextrin (146157717) -- Butyl sultone (14747178) -- Chitin (6857375) -- Chitosan (71853) -- Glycol chitosan (155819511) -- Acetic acid (176) -- Poloxamer 407 (24751) -- Polyethylene glycol 400 (91975) -- TMPyP (135398505); 3D Three dimension -- ACV Acyclovir -- AD Alzheimer's disease -- ADR Adriamycin -- AMD Amiodarone hydrochloride -- AML Amlodipine -- API Active pharmaceutical ingredient -- AS Asiaticoside -- AUC Area under the curve -- BCS Biopharmaceutical classification system -- CBZ Carbamazepine -- CDs Cyclodextrins -- CEBPβ CCAAT-enhancer-binding protein beta -- CS Chitosan -- CHL Chloramphenicol -- CHR Chrysin -- CLSM Confocal laser scanning microscopy -- COVID-19 Corona virus disease 2019 -- CR Curcumin -- CVDs Cardiovascular diseases -- DA Dopamine -- DS Degree of substitution -- DTX Docetaxel -- Dex Dexamethasone -- ECO Econazole nitrate -- Erlo Erlotinib -- FDA Food and drug administration -- GCS Glycol chitosan -- GLA Glaucocalyxin A -- HI Hypoxia-ischemia -- HLK Honokiol -- HLE Hot liquid extrusion -- HME Hot melt extrusion -- HPLC High performance liquid chromatography -- HP-β-CD Hydroxypropyl-β-cyclodextrin -- IBR Ibrutinib -- ICs Inclusion complexes -- IM Intramuscular -- IV Intravenous -- LVF Levofloxacin -- NDs Nanodroplets -- NFs Nanofibers -- NPs Nanoparticles -- NSCLC Non-small cell lung cancer -- PAH Pulmonary arterial hypertension -- PCZ Posaconazole -- Peff Effective permeability coefficient -- PLGA poly(lactic-co-glycolic acid) -- RCa Rosuvastatin calcium -- SAE CDs Sulfoalkylated cyclodextrins -- SBE-β-CD Sulfobutylether-β-cyclodextrin -- SDACNFs Surface-deacetylated chitin nanofibers -- SEV Sevoflurane -- SEM Scanning electron microscopy -- SFO Sulfisoxazole -- SRB Sulforhodamine B -- TEER Transepithelial electrical resistance -- Tol Toltrazuril -- TMPyP 5, 10, 15, 20-Tetrakis-(1-methyl-4-pyridino)porphyrin -- WHO World health organization; Sulfobutylether-β-cyclodextrin -- Inclusion complex -- Drug delivery -- Nanoparticles -- Cancer -- Captisol; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.120347
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility (>50 folds compared to β-CD), improved stability, and biocompatibility that praised SBE-β-CD as a smart polymer for drug delivery applications. Commercially, SBE-β-CD is popular by its brand name Captisol®. The present review discusses the structure, properties, and preparation methods of SBE-β-CD-based inclusion complexes (ICs). Furthermore, we discuss here the preparation and applications of SBE-β-CD ICs-based nanoparticulate drug delivery systems, which combines the merits of both, ICs (enhanced solubility) and nanoparticles (NPs, targeted therapy). Patents on and FDA-approved Captisol®-enabled products are tabulated in the benefit of readers. The toxicological aspects and current clinical status of SBE-β-CD or SBE-β-CD-based products are briefly explained in the present review. In our opinion, the present review would be a pathfinder to allow dissemination of information on SBE-β-CD. Graphical abstract: Unlabelled Image Highlights: Sulfobutylether-β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide. SBE-β-CD is used to improve the solubility, and stability of small molecules. It lessens the volatility, irritation, and hides smell or taste of small molecules. Present review is the state-of-the-art collection on SBE-β-CD. SBE-β-CD is an emerging functional biopolymer for drug delivery.