Evaluation of Riboflavin as an enhancer for X-ray and EBeam irradiation treatment of Tulane virus. (February 2023)

• Record Type: Journal Article
• Authors: Kingsley, David H.; Chang, Sam K.C.; Annous, Bassam A.; Pillai, Suresh D.
• Is Part Of: Radiation physics and chemistry. Volume 203(2023)Part A
• Publication Date: 2023-02
• Subjects: Foodborne virus -- X-ray -- EBeam -- Singlet oxygen; Radiation chemistry -- Periodicals; Radiometry -- Periodicals; Radiation -- Periodicals; Chimie sous rayonnement -- Périodiques; 539.2
• DOI: 10.1016/j.radphyschem.2022.110645
• Languages: English
• ISSNs: 0969-806X

Abstract

Abstract: Ionizing technologies rely on high doses of irradiation to achieve 5-log reduction of foodborne viruses. We hypothesized that riboflavin (vitamin B2 ), a singlet oxygen enhancer could synergize the virucidal effects of electron beam (eBeam) and X-ray doses by using Tulane virus as a model virus. Concentrations of up to 1% w/v riboflavin were evaluated against 1 kGy X-ray treatments. Also 0.1% riboflavin was evaluated against eBeam treatments up to 10 kGy. The results showed that riboflavin did not enhance the sensitivity of Tulane virus to either eBeam or X-ray treatments. Highlights: Ionizing technologies have limited effectiveness against foodborne viruses. Singlet oxygen is powerful disinfectant generated by light and enhancers. Riboflavin, a singlet oxygen enhancer, is depleted by irradiation. Hypothesis: irradiation effectiveness against viruses might be enhanced by riboflavin. Conclusion: riboflavin did not enhance eBeam or X-ray effectiveness against Tulane virus.